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Bone regenerative engineering via controlled release of simple signaling molecules
(University of Missouri--Columbia, 2018)
in the defect site, most commonly utilizing calcium phosphates in their design to mimic the inorganic phase of bone. Most of previous research has overlooked that calcium phosphates consist of two non-proteinous signaling molecules calcium ions (Ca2...
Novel biomaterials for controlled immunomodulatory drug delivery
(University of Missouri--Columbia, 2022)
immunosuppressant therapies, the impact micellar physical properties have on incorporated bioactive peptides determined from this research will help us continue to understand structure-function relationships more broadly for nanoparticle-based drug delivery systems...
Peptide Amphiphile micelles (pams)-biomolecular materials capeble of modulating the immune system
(University of Missouri--Columbia, 2018)
amphiphile chemistry. This is crucial for PAM vaccine development as size has been previously reported to have tremendous impact on immunogenicity. This chapter is adapted from my publication in ACS Biomaterials Science & Engineering. In the third chapter, I...
Engineering novel biomolecular materials for therapeutic peptide payload delivery
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Hematological cancers, including leukemia and lymphoma, are estimated to cause the death of 58,000 people in the United States in 2018 and account for ...